Prolozone, Prolozone, Arcadia Plastic Surgeon Dr George Sun


  • Prolozone is a technique that combines Prolotherapy and ozone therapy to treat musculoskeletal conditions such as knee osteoarthritis, spinal disc herniations, rotator cuff injuries, and other pain associated with the joints.
  • Ozone (O3) is a gas at room temperature and is made up of three oxygen molecules. The mechanism behind ozone is that it stimulates circulation, improves oxygen utilization, stimulates cytokines, and directly kills microbes. Over time, ozone gas dissociates back into oxygen, which can act as a nutrient for joint tissue to regenerate.
  • Prolotherapy: Prolozone does not cause as much pain as prolotherapy. Inflammation caused by prolotherapy can last for weeks, while prolozone may only cause some slight swelling for a couple days. Prolotherapy would require multiple sessions to produce similar results as a few treatments of prolozone.
  • Steroid Injections: Steroid injections can be used to bring relief from joint pain by reducing inflammation and edema. But constant use of steroids may lead to joint degeneration, which may further worsen the joint pain over time. Prolozone not only helps relieve pain, but it also help regenerate connective tissue around the joint, bringing stability to the joint, thus reducing pain long after the treatment.
  • Chronic neck
  • Chronic back pain
  • Rotator cuff injuries
  • Degenerative and arthritic hips and knees
  • Degenerated discs
  • Plantar fasciitis
  • Carpal tunnel syndrome
  • TMJ
  • Sciatica
  • Neuromas
  • Tennis elbow
  • Post-orthopedic surgery pain
  • Scars
  • Sports injuries
  • Patients with realistic expectation
  • Patients in good healthy conditions
  • Stable weight without frequent or excess weight gain or loss
1. Patients with unrealistic expectation
2. Patients with low blood sugar, dehydration, acute disease, autoimmune disorder, blood disorder, cancer, or on bleeding thinning medications.
The procedure involves numbing the skin with a cold spray, then performing an injection with a small needle into the affected joint. A single entry point will be needed with each treatment area, where anesthetic will first be injected to numb the joint. B-vitamins are also included to increase the efficacy of the treatment. Ozone gas will be injected last, which may initially cause discomfort in the joint due to increased pressure from the gas. The discomfort will dissipate within a few minutes, though soreness may persist for 1-2 days.
  • Reduction of joint pain and increased stability/balance.
  • Increased range of motion for certain joints.
There will be relief of joint pain within 24 hours.
With one treatment, pain relief will last between 2-4 weeks. With each additional treatment, there will be longer-lasting pain reduction and increased stability of the joint due to regeneration of ligaments and tendons around the joint.

  • Moderate swelling, mild bruising, and mild pain are expected.
  • You may experience pressure and soreness for 1-2 days in treatment area. The treated joint may release sound during movement due to the ozone gas being dispersed.
  • Prescription pain medications are generally not necessary. Ice can be used for lingering pain.
  • Most people return to work and activities in a few days.
  • Wear appropriate clothes to allow easy access to joint.
  • Stay hydrated before and after treatment.
  • No NSAIDs (Advil, Ibuprofen, Celebrex, diclofenac) 24 hours before treatment.
  • No strenuous activity for at least 24 hours after treatment.
  • No NSAIDs (Advil, Ibuprofen, Celebrex, diclofenac) 48 hours after treatment.
  • Ice can be used 2-3 times a day after treatment.
Cost of treatment options ranges from three to four digits. An in-person consultation with your specialist physician will help to determine the best suitable solution to your own individual needs.