Exosomes

Cellular released elements such as exosome and growth factors are potent protein biomolecules produced upon stimulation by a broad range of cells and exert tremendous effects on cell signaling. These factors heal damage, reduce inflammation, control the immune system, promotes growth, stimulate microcirculation, and participate in tissue engineering. 

In essence, the ultimate benefits of stem cells may be the potent bioactive molecules released by stem cells. More and more recent research have demonstrated that cellular derived elements, the potent signaling cytokines and bioactive molecules, rather than the cells themselves, may be responsible for the reparative and regenerative capacity.

Cellular released elements of biomolecules can be sourced from ones’s own blood in the form of PRP, platelet rich plasma.

Cellular released elements of biomolecules can also be sourced from ones’s own blood in the form of neonatal placental umbilicus in the form of Umbilical Cord Extract.

What are stem cells?

Stem cells enhancement may help you to repair and regenerate!!

Stem cells are specialized cells with two specialized functions:  self renewal by creating cells of same type, and differentiation by creating different cell types.

Stem cells are unspecialized cells which give rise to specialized cells.  In other words, all other cells in a developing body stem from these cells. Stem cells can renew themselves by cellular division and can also differentiate into other cells.  In the early stage of an embryo, stem cells are pluripotent, meaning that they can develop into any cells.  From birth onward, stems cells become multipotent, meaning that they can only develop into certain designated cell types.

Many stem cell types exist.  Found in blood, bone marrow, and umbilical cord, hematapoetic stem cells are stem cells which can differentiate into blood cells.  Found in bone marrow, fat, umbilical, and umbilical cord, mesenchymal stem cells can differentiate into bone, cartilage, muscle, and fat.

Stem cells most likely are found in the lining of tiny capillaries throughout the body. 

With aging, the number and functionality of stem cells decline, and the rate of destruction and wearing out of stem cells increases.  As such, stem cells cannot be produced in sufficient quantity and quality compared to the rate of destruction, cellular function eventually declines progressively.

Is aging of stem cells the only reason for our aging?

The causes of aging are numerous, ranging from genetic to acquired causes.  Only a handful of causes can be clinically treated.  These include lifestyle, detoxification, antioxidant, free radicals, chronic inflammation, hormonal imbalance, decreased immunity, decreased DNA repair, and ultimately stem cell decline.  Consequently, the ultimate result of accelerated aging is, of course, DNA aging. 

Thus, optimized antiaging regimen requires treatment of multiple causes, not just stem cells.

Source of Stem Cells

Adult stem cells are harvested from adult blood, bone marrow, and fat, whereas neonatal stem cells are harvested from umbilical cord blood and umbilical cord tissue.

Pure stem cell products containing only stem cells are derived from umbilical cord blood.  The preparation is processed and manipulated by pharmaceutical companies in FDA approved facilities.  These products are pure stem cells and are considered as drugs.  Currently, the only FDA approved pure stem cell product is for certain blood diseases.

Products containing both stem cells and non-cellular components can be derived from one’s own tissue of blood, fat, and bone marrow.  The preparation is processed by doctors in under clinical protocols in clinic or hospital settings for same day injection.  The preparations contain both cellular and non-cellular components.  These preparations are considered as grafts and not drugs.  Since adult cells are aged, both the quality and quantity of preparation are less.

Products contain both stem cells and non-cellular components can also be derived from neonatal placenta and umbilical cord.  The preparation is processed by laboratories under FDA guidance in FDA approved facilities for subsequent storage and injection.  The products also contain both cellular and non-cellular components.  The products are also considered as grafts and not drugs.  Since neonatal cells are very young, both the quality and quality of preparation are greatly enhanced.

Are stem cells considered as drugs?

Biological products are not considered as drugs by the FDA when they:

1.     Have no significant manipulation
2.     Homologous use
3.     not combined with ingredients other than FDA approved list
4.     do not have systemic effect and are not dependent on cells

How do stem cells work?

Stem cells primarily restore, repair, regenerate, and rejuvenate.

When disease, injury, trauma, or inflammation occurs, the damaged sites typically have a low oxygen environment.  At these damaged sites, the micro blood vessels become sickened and release biochemical signals to attract the stem cells to come to help. 

Stem cells will then become activated and “home” into these disease sites to restore, repair, and regenerate.  When stem cells are injected intravenously, the majority of the cells ends up in the lungs but a minority still seem to be able to home in and target the whole body for multiple disease sites.  Alternatively, when stem cells are injected into or near a localized disease site, these cells seem to concentrate on that particular damaged area.

Even though injected stem cells may stay at the disease sites for a very short period of time for about two days, stem cells exert a tremendous degree of healing power.  When attracted to these disease sites, these stem cells secrete celluar elements of potent biochemical signals to activate other cells and recruit more local stem cells.  In turn, more numerous biomolecules are made.  Injected stem cells also stimulate the local stem cells to regenerate into needed cells to replace the damaged cells to heal.

Stem cells functions are optimized by laser stimulation, antoxidant energization, cytokines enrichment, free radical reduction, hormone replenishment, and improved DNA repair.

What is the safety of stem cells?

For the past three decades, stem cells rich bone marrow has been used in nearly ninety diseases, and umbilical cord blood has been used for blood derived cancers.  These treatments have been safe and effective, without significant stem cell related diseases or cancers.

In select settings, stem cells have also been used to treat:

1.     Skin:  acceleration of wound repair and healing
2.     Cosmetic:  hair loss, tissue engineering
3.     Cardiovascular: heals damaged heart
4.     Immunity:  regulates the immune system
5.     Respiratory:  improves respiratory function
6.     Metabolic:  normalizes blood sugar
7.     Reduces inflammation
8.     Improves liver/kidney function
9.     Neurological:  cerebral palsy, traumatic brain injury, stroke, multiple sclerosis, Alzheimer’s disease,
10. Musculoskeletal:  osteoarthritis, fibromyalgia, osteoporosis, injury
11. Eyes:  diabetic retinopathy and macular degeneration
12. Sexual function:  improves sexual functions

How to compare the stem cell containing products?

1. Realize that stem cells function best when other body function are optimized.  As such, when only stem cell preparation is given, the effects can be short-lived, minimal, unnatural, imbalanced, and requiring very high cost and dosages.  The factors which need to be optimized simultaneously include exercise, diet, sleep, stress reduction , antioxidant and free radical levels balancing, detoxification, hormonal balance, cytokines and growth factors, and DNA repair.

As such, a patient can choose to receive only regenerative stem cell containing injection, or a more comprehensive approach to stem cells.

2. Recognize the difference between adult and neonatal preparation of stem cell products.  Recall that neonatal products have much younger cells and thus both the cellular and non-cellular component have significantly higher functionality and capability.

3. Determine local versus antiaging effects desired.  For local repair, non-celluar components of scaffolding proteins and extracellular matrix are important.  For anti-aging, live cells are important.  For growth, cytokines and growth factors are essential. 

4. Request a certificate of analysis for laboratory preparation to determine class 361, 351, or Investigation drug category, FDA registration, compliance, live cell count, cellular characterization, non-cellular elements count, and regenerative capacities such as CFC(colony formation unit) count and other reparative studies.

5. Review before and after diagnostic testing to see results of all anti-aging treatment to examine objective improvements.

Umbilical Stem Cells

What do living placenta and umbilical cord contain?

Umbilical and umbilical cord tissue provides both protection and nourishment.  Umbilical and umbilical cord numerous highly powerful bioactive molecules and stem cells, which all can aid repair of the body. 

Residing inside the umbilical and cord, stem cells help to repair, regenerate and rejuvenate the body.  These cells have not acquired genetic markers and thus are immune from rejection by both the mother and other recipients. These cells can home in to areas of disease, seed targeted areas, and begin renewal, differentiation, and repair.  These cells can also secrete numerous potent signaling cytokines to promote differentiation, reduce inflammation, stimulation one’s own stem cells, and control the immune system.

How are umbilical cord stem cells different from adult stem cells?

Adult stem cells derived from one’s bone marrow or fat.  The functionality of these aging cells is much lower than the young umbilical umbilical cord stem cells.  Compared to adult stem cells, these young perinatal stem cells are much more capable of regeneration and repair.  For example, stem cells at birth are capable of making 1 billion stem cells in one month, whereas adult stem cells at age 60 can only make 200 cells every month. 

How is umbilical cord extract prepared?

Umbilical Cord Extract uses human placental and umbilical cord extract in flowable fluid form.

Umbilical cord and amniotic tissue are obtained from umbilicals during cesarean section from health screened and tested mothers, processed into flowable fluid extract, with growth factors and/or cells extracted and frozen with liquid nitrogen to -196 degree Celsius to preserve stability.  The extraction process maximizes stem cell function and viability A stabilizer called DMSO is subsequently added as a cryoprotectant.  Individuals with known sensitivity towards DMSO should not use tissue prepared containing DMSO.

Umbilical cord extract contains specialized reparative, regenerative, immune modulating, anti-inflammatory, growth promoting, microcirculation stimulating, and stem cell stimulating healing signaling cytokines and cells.

Biologic tissue are collected, processed, screened, tested, stored, and distributed I compliance with all FDA regulations concerning HCT/Ps.  Despite all these safety measures, no claim of complete safety and biological properties can be made.  As such, occurrence of complication can include but is not limited to transmission of communicable disease, transmission of infectious disease, and/or immune or allergic reaction to implanted or injected biologic product.

Umbilical cord extract cell-containing graft is sourced at Chara Biologics.  Each cc of umbilical cord extract contains up to 10 million live cells and hundreds of types of bioactive molecules. 

Umbilical cord extract non-cellular exosome is sourced at Evovex.  Each cc of umbilical cord extract contains up to 5 billions nano-sized exosome bioactive molecules.

CordStemSM is an intramuscular or subcutaneous injection of laser stimulated, antioxidant energized, and autologous blood stem cell enriched umbilical cord extract cell-containing graft.  Via proprietary technique, the umbilical cord reparative, regenerative, immune modulating, anti-inflammation, and stem cell stimulating cytokines are laser stimulated, antioxidant energized, and autologous stem cell enriched to optimize rejuvenation.

For body’s internal repair and rejuvenation purpose, CordStem is administered intramuscularly or subcutaneously.  For external cosmetic tissue regenerative purpose, CordStem is administered locally into the soft tissue.  Low level light exposure, antioxidant micronutrient rich environment, and growth factors all further optimize, stimulate, and energize stem cell functioning. 

As such, CordStem is:

More convenient than surgical fat stem cells

More regenerative than aging adult stem cells

More energized than traditional umbilical injection

This treatment is for individuals desiring:

1.     Easy, simple, convenient, and more potent regenerative rejuvenation, without surgery
2.     Both simultaneous internal and external antiaging

ExoStemSM is an intramuscular or subcutaneous injection of laser stimulated, antioxidant energized, and autologous blood stem cell enriched umbilical cord extract non-cellular exosomes.  Via proprietary technique, the umbilical cord reparative, regenerative, immune modulating, anti-inflammation, and stem cell stimulating cytokines are laser stimulated, antioxidant energized, and autologous stem cell enriched to optimize rejuvenation.

For body’s internal repair and rejuvenation purpose, ExoStem is administered intramuscularly or subcutaneously.  For external cosmetic tissue regenerative purpose, ExoStem is administered locally into the soft tissue.  Low level light exposure, antioxidant micronutrient rich environment, and growth factors all further optimize, stimulate, and energize stem cell functioning. 

As such, ExoStem is:

More convenient than surgical fat stem cells

More regenerative than aging adult stem cells

More energized than traditional umbilical injection

More direct action oriented from biomolecules, non-cellular, and smaller in size than cells.

This treatment is for individuals desiring:

1.     Easy, simple, convenient, and more potent regenerative rejuvenation, without surgery
2.     Both simultaneous internal and external antiaging

Autologous Blood Stem Cells

BloodStemSM is an intramuscular or subcutaneous injection of laser stimulated, antioxidant energized, and signaling cytokines enriched autologous blood stem cells.  Via proprietary technique, the autologous blood derived stem cells extract reparative, regenerative, immune modulating, anti-inflammatory, and stem cell stimulating cytokines are laser stimulated, antioxidant energized, and autologous growth factors enriched to optimize rejuvenation.

This technique utilizes your own blood derived blood stem cells and signaling cytokines.  This processed, fractionated, and activated portion of the plasma from your blood is an advanced version of a common procedure known as platelet rich plasma, or PRP.  This fractionated portion has been shown to contain both blood stem cells and numerous growth factors and signaling cytokines.

As such, BloodStem is:

Completely one’s own stem cells for regenerative rejuvenation

More convenient than surgical fat stem cells

Most cost effective option

This treatment is for individuals desiring:

1.     Easy, simple, convenient, and cost effective regenerative rejuvenation, without surgery
2.     Both simultaneous internal and external antiaging

Autologous Fat Stem Cells

LipoStemSM is an intramuscular or subcutaneous injection of laser stimulated, antioxidant energized, and autologous blood stem cell and growth factors enriched autologous fat stem cells extract.  Via proprietary technique, the autologous fat stem cells extract reparative, regenerative, immune modulating, anti-inflammatory, and stem cell stimulating cytokines are laser stimulated, antioxidant energized, and autologous stem cell and growth factors enriched to optimize rejuvenation.

This technique utilizes your own fat derived fat stem cells and signaling cytokines.  Your own fat is harvested with liposuction under local anesthesia and is processed and fractionated to produce a fat stem cells extract known as stromal vascular fraction.  This fractionated portion has been shown to contain both fat stem cells and numerous growth factors and signaling cytokines. 

For every two hundred cc of fat processed and fractionated, about 30 million live stem cells are obtained from the stem cells extract known as stromal vascular fraction.  

As such, LipoStem is:

Completely your own fat stem cells and blood stem cells

surgically oriented with added benefit of liposuction

This treatment is for individuals desiring:

1.     Completely one’s own stem cells for regenerative rejuvenation, with the added benefit of surgical liposuction
2.     Both simultaneous internal and external antiaging